December 30, 2017


The science behind regulatory B cell-based therapies for oncology, autoimmunity and immunodeficiency has been featured in many leading peer-reviewed publications.

  1. Matsushita T, Fujimoto M, Hasegawa M, Komura K, Takehara K, Tedder TF, Sato S. Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response. J. Pathol. 2006; 168:812-821.
  2. Watanabe R, Fujimoto M, Ishiura N, Kuwano Y, Nakashima H, Yazawa N, Okochi H, Sato S, Tedder TF, Tamaki K. CD19 expression in B cells is important for suppression of contact hypersensitivity. Am J Pathol. 2007; 171:560-570.
  3. Yanaba K, Bouaziz J-D, Haas KM, Poe JC, Fujimoto M, Tedder TF. A regulatory B cell subset with a unique phenotype controls T cell-dependent inflammatory responses. Immunity 2008; 28:639-650. This article was the focus of the cover story “Scientists prove existence of regulatory B-cell subset” published in Autoimmune Drug Focus. Issue No. 43, July 2008, page 1.
  4. Yanaba K, Bouaziz J-D, Matsushita T, Magro CM, St.Clair WE, Tedder TF. B lymphocyte contributions to human autoimmune disease. Immunological Rev. 2008; 223:284-299.
  5. Bouaziz J-D, Yanaba K, Tedder TF. Regulatory B cells as inhibitors of immune responses and inflammation. Immunological Rev. 2008; 224:201-214.
  6. Matsushita T, Yanaba K, Bouaziz J-D, Fujimoto M, Tedder TF. Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression. J Clin Invest. 2008; 118:3420-3430. Article was the focus of an accompanying review article, Kurosaki T. “Paradox of B cell-targeted therapies” J Clin Invest. 2008; 118:3260-3263; highlighted in subsequent reviews “Balancing B-cell subsets in EAE” Nature Rev Immunol. 2008; 8:825 and “Course of mouse autoimmune disease is shaped by paradoxical B cell roles” Nature Clin.Practice Rheum. 2009; 5:3-4.
  7. Matsushita T, Tedder TF. B lymphocyte depletion for the treatment of multiple sclerosis: now things really get interesting. Expert Rev Neurother. 2009; 9:309-312.
  8. DiLillo DJ, Matsushita T, Tedder TF. B10 and regulatory B cells balance immune responses during inflammation, autoimmunity and cancer. In: The Year in Immunology. Ann NY Acad Sci. 2010: 1183:38-57. This article was ranked in the top 500 of one of the 256 scientific categories (176 of 92,018 articles, Immunology) indexed in Web of Science for 2010 to 2014 (data collected 1/2/16).
  9. Yanaba K, Bouaziz JD, Matsushita T, Tsubata T, Tedder TF. The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. J Immunol. 2009; 182:7459-7472. This article was featured in a review article, Leslie, M. Take-charge B cells create buzz. Science 2009; 325:144-145.
  10. Matsushita T, Tedder TF. Identifying regulatory B cells (B10 cells) that produce IL-10. Methods Mol Biol. 2011; 677:99-111.
  11. Haas KM, Watanabe R, Matsushita T, Nakashima H, Ishiura N, Okochi H, Fujimoto M, Tedder TF. Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 J Immunol. 2010; 184:4789-4800.
  12. Watanabe R, Ishiura N, Nakashima H, Kuwano Y, Okochi H, Tamaki K, Sato S, Tedder TF, Fujimoto M. Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity. J Immunol. 2010; 184:4801-4809.
  13. Tedder TF, Matsushita T. Regulatory B cells that produce IL-10: A breath of fresh air in allergic airway disease. J Allergy Clin Immunol. 2010; 125:1125-1127.
  14. Matsushita T, Horikawa M, Iwata Y, Tedder TF. Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling EAE initiation and late-phase immunopathogenesis. J Immunol. 2010; 185:2240-2252. This article was ranked in the top 500 of 1 of the 256 scientific categories (442 of 92,018 articles, Immunology) indexed in Web of Science for 2010 to 2014 (data collected on Jan.2 2016).
  15. Iwata Y, Matsushita T, Horikawa M, DiLillo DJ, Yanaba K, Venturi GM, Szabolcs PM, Bernstein SH, Magro CM, Williams AD, Hall RP, StClair EW, Tedder TF. Characterization of a rare IL-10-competent B cell subset in man that parallels mouse regulatory B10 cells. Blood 2011; 117:530-541. This article was ranked in the top 500 of 1 of the 256 scientific categories (24 of 46,673 articles, Hematology) indexed in Web of Science for 2010 to 2014 (data collected on Jan.2 2016).
  16. Yanaba K, Yoshizaki A, Asano Y, Kadono T, Tedder TF, Sato S. IL-10-producing regulatory B10 cells inhibit intestinal injury in a mouse model. Am J Pathol. 2011; 178:735-743.
  17. DiLillo DJ, Griffiths R, Seshan SV, Magro CM, Ruiz P, Coffmann TM, Tedder TF. B lymphocytes differentially influence acute and chronic allograft rejection in mice. J Immunol. 2011; 186:2643-2654.
  18. DiLillo DJ, Horikawa M, Tedder TF. B cell effector mechanisms in health and disease. Immunol Res. 2011; 49:281-292.
  19. Poe JC, Smith S-H, Haas KM, Yanaba K, Tsubata T, Matsushita T, Tedder TF. Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice. PLoS One 2011; 6: e22464.
  20. Horikawa M, Minard-Colin V, Matsushita T, Tedder TF. Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice. J Clin Invest. 2011; 121:4268-4280. This article was highlighted in the “In This Issue” section; “B cells bad for lymphoma therapy” J Clin Invest. 2011; 121:4205.
  21. Maseda D, Smith SM, DiLillo DJ, Bryant JM, Candando KM, Weimer ET, Weaver CT, Tedder TF. Regulatory B10 cells differentiate into antibody-secreting cells after transient IL-10 production in vivo. J Immunol. 2011; 188:1836-1048.
  22. DiLillo DJ, Weinberg JB, Yoshizaki A, Horikawa M, Bryant JM, Iwata Y, Matsushita T, Matta KM, Chen Y, Venturi GM, Russo G, Gockerman JP, Moore JO, Diehl LF, Volkheimer AD, Friedman DR, Lanasa MC, Hall RP, Tedder TF. Chronic lymphocytic leukemia and regulatory B cells share IL-10-competence and immunosuppressive function. Leukemia 2013; 27:170-182. This article was highlighted in “B10 cells and immunosuppression in CLL” by JC Byrd in the Am Soc Hematology newsletter The Hematologist Nov-Dec 2012.
  23. Yoshizaki A, Miyagaki T, DiLillo DJ, Matsushita T, Horikawa M, Kountikov EI, Spolski R, Poe JC, Leonard WJ, Tedder TF. Regulatory B cells control T cell autoimmune disease through IL-21-dependent cognate interactions. Nature 2012; 491:264-268. (PMCID: PMC3493692). This article was highlighted in “Breg-ging rights”, L Osherovich, SciBX 5(42); doi:10.1038/scibx.2012.1103. Published online Oct. 25, 2012. This article was reviewed in “IL-21 induces B10 cell function” by O Leavy, Nature Rev Immunol. 2012; 12:208-209.
  24. Horikawa M, Weimer ET, DiLillo DJ, Venturi GM, Spolski R, Leonard WJ, Heise MT, Tedder TF. Regulatory B cell (B10 cell) expansion during Listeria infection governs innate and cellular immune responses in mice. J Immunol. 2013; 190:1158-1168.
  25. Kalampokis I, Yoshizaki A, Tedder TF. IL-10-producing regulatory B cells (B10 cells) in autoimmune disease. Arthritis Res Therapy 2013; 15(Suppl. 1):S1.
  26. Huu DL, Matsushita T, Jin G, Hamaguchi Y, Hasegawa M, Takehara K, Tedder TF, Fujimoto M. Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease. Blood 2013; 121:3274-3283.
  27. Yanaba K, Kamata M, Ishiura N, Shibata S, Asano Y, Tada Y, Sugaya M, Kadono T, Tedder TF, Sato S. Regulatory B cells suppress imiquimod-induced psoriasis-like skin inflammation" J Leukoc Biol. 2013; 94:563-573. (PMCID: PMC3774845). This article was highlighted in “Editorial: are regulatory B10 cells a viable target for autoimmune diseases?” By: BJ Barnes, J Leukoc Biol. 2013; 548-550.
  28. Maseda D, Candando KM, Smith SH, Kalampokis I, Weaver CT, Plevy SE, Poe JC, Tedder TF. Peritoneal cavity regulatory B cells (B10 cells) modulate IFN-γ+CD4+ T cell numbers during colitis development in mice. J Immunol. 2013; 191:2780-2795.
  29. Yanaba K, Kamata M., Asano Y, Tada Y, Sugaya M. Kadono T, Tedder TF, Sato S. CD19 expression in B cells regulates atopic dermatitis in a mouse model. Am J Pathol. 2013; 182:2214-2222.
  30. Candando KM, Lykken JM, Tedder TF. B10 cell regulation of health and disease. Immunol Rev. 2014; 259:259-272.
  31. Tedder TF, Leonard WJ. Regulatory B cells control autoimmunity: IL-35 and IL-21 regulate the regulators. Nat Rev Rheum. 2014; 10:452-453.
  32. Tedder TF. B10 cells – a functionally defined regulatory B cell subset. J Immunol. 2015; 194:1395-1401.
  33. Tedder TF. Introduction: regulatory B cell special issue, making all the pieces fit. Int Immunol. 2015; 27:467-470.
  34. Lykken JM, Candando KM, Tedder TF. Regulatory B10 cell development and function. Int Immunol. 2015; 27:471-477.
  35. Kalampokis I, Venturi GM, Poe JC, Dvergsten JA, Sleasman JW, Tedder TF. The regulatory B cell compartment expands transiently during childhood and is contracted in children with autoimmunity. Arthritis Rheum. 2016; 69:225-238.